Depletion of ATP and Oxidative Stress Underlie Zinc-Induced Cell Injury
نویسندگان
چکیده
منابع مشابه
Alterations in zinc homeostasis underlie endothelial cell death induced by oxidative stress from acute exposure to hydrogen peroxide.
Oxidative stress has been associated with multiple pathologies and disease states, including those involving the cardiovascular system. Previously, we showed that pulmonary artery endothelial cells (PAECs) undergo apoptosis after acute exposure to H(2)O(2). However, the underlying mechanisms regulating this process remain unclear. Because of the prevalence of H(2)O(2) in normal physiological pr...
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Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI). Materials ...
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ژورنال
عنوان ژورنال: Acta Medica (Hradec Kralove, Czech Republic)
سال: 2007
ISSN: 1211-4286,1805-9694
DOI: 10.14712/18059694.2017.58